Profile

Professional career

• since 07/2020
  W3 Professor of Environmental Pediatric Immunology, Leipzig UNiversity
• since 06/2020
  Head of the Department Environmental Immunology, Helmholtz Centre for Environmental Research -UFZ- & Perinatal Immunology Research Group, Saxonian Incubator for Clinical Translation, Medical Faculty, UL
• 01/2007 - 05/2020
  W2 Professor of Experimental Obstetrics and Gynecology, Medical Faculty, Otto-von-Guericke University, Magdeburg
• 01/2003 - 05/2007
  Principal Investigator and Work Group Leader, Charité, Medical University, Berlin, Germany

Education

• 02/2006
  Habilitation, Charité-Universitätsmedizin Berlin, venia legendi Immunology
• 05/2001
  PhD Immunologie, Universidad de Buenos Aires, Argentinien
• 09/1990 - 05/1996
  Biochemie Studium, Universidad Nacional del Litoral, Argentinien

My research interest is the understanding of immunological mechanisms that underlie maternal tolerance towards paternally derived fetal antigens during pregnancy. I particularly care about perinatal events associated with pregnancy success and pathologies associated with their dysregulation. We first reported antigen specific regulatory T cells (Treg) as main regulators of pregnancy. My group also described the relevance of the fetal hormone human chorionic gonadotropin (hCG) in modulating immune cells towards tolerance. In the last years, we have focussed on unveiling how environmental chemicals and in particular endocrine disrupting chemicals (EDCs) interfere with these mechanisms. Using models of perinatal exposure to EDCs, we seek to unveil long-term effects in the progeny and the underlying mechanisms. Our research relies on the use of complex state of the art in vitro approaches likewise the use of organoids as well as the validation of the results in mouse models and samples obtained in the context of human cohorts.

• Deutsches Zentrum für Kinder und Jungendgesundheit (DZKJ) - Standort Leipzig/Dresden - SaxoChiLD

  Körner, Antje

  Duration: 04/2024 – ongoing

  Funded by: BMBF Bundesministerium für Bildung und Forschung

  Involved organisational units of Leipzig University: Leipziger Forschungszentrum für Zivilisationserkrankungen (LIFE); Medizinische Fakultät; Helmholtz-Institut für Metabolismus, Adipositas und Gefäßforschung
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• ENDOMIX – Understanding how endocrine disruptors and chemical mixtures of concern target the immune system to trigger or perpetuate disease

  Zenclussen, Ana Claudia

  Duration: 12/2023 – ongoing

  Funded by: EU Europäische Union

  Involved organisational units of Leipzig University: Leipziger Forschungszentrum für Zivilisationserkrankungen (LIFE)
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• Leipzig Reproductive Health Research (LE-REP) Center

  Zenclussen, Ana Claudia

  Duration: 01/2023 – ongoing

  Funded by: BMBF Bundesministerium für Bildung und Forschung

  Involved organisational units of Leipzig University: Leipziger Forschungszentrum für Zivilisationserkrankungen (LIFE); Geburtskunde und Gynäkologie; Institut für Laboratoriumsmedizin, Klinische Chemie und Molekulare Diagnostik; Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie
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• PARC – partnership for the assessment of risks from chemicals (WP5)

  Zenclussen, Ana Claudia

  Duration: 09/2022 – ongoing

  Funded by: EU Europäische Union

  Involved organisational units of Leipzig University: Leipziger Forschungszentrum für Zivilisationserkrankungen (LIFE)
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• CoViPa – Virological and immunological determinants of COVID-19 pathogenesis – lessons to get prepared for future pandemics (consortium) – SP3

  Zenclussen, Ana Claudia

  Duration: 10/2021 – ongoing

  Funded by: Andere öffentliche Bereiche

  Involved organisational units of Leipzig University: Leipziger Forschungszentrum für Zivilisationserkrankungen (LIFE)
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more projects

• Braun, G.; Herberth, G.; Krauss, M.; König, M.; Wojtysiak, N.; Zenclussen, A. C.; Escher, B. I.

  Neurotoxic mixture effects of chemicals extracted from blood of pregnant women

  Science. 2024. pp. 301–309.

  DOI: 10.1126/science.adq0336
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• Fischer, F.; Kretschmer, T.; Seifert, P.; Howanski, J.; Krieger, E.; Ro, J.; Fink, B.; Yin, Z.; Bauer, M.; Zenclussen, M. L.; Meyer, N.; Schumacher, A.; Zenclussen, A. C.

  Single and combined exposures to bisphenol A and benzophenone-3 during early mouse pregnancy have differential effects on fetal and placental development

  Science of the Total Environment. 2024.

  DOI: 10.1016/j.scitotenv.2024.171386
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• Busse, M.; Langwisch, S.; Tedford, K.; Fischer, K.-D.; Zenclussen, A. C.

  Maternal B cell signaling orchestrates fetal development in mice

  Development. 2022. 149 (8, SI).

  DOI: 10.1242/dev.199783
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• Holder, B.; Aplin, J. D.; Gomez‐Lopez, N.; Heazell, A. E. P.; James, J. L.; Jones, C. J. P.; Jones, H.; Lewis, R. M.; Mor, G.; Roberts, C. T.; Robertson, S. A.; Zenclussen, A. C.

  ‘Fetal side’ of the placenta: anatomical mis-annotation of carbon particle ‘transfer’ across the human placenta

  Nature Communications. 2021. 12 (1).

  DOI: 10.1038/s41467-021-26437-y
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• Linzke, N.; Schumacher, A.; Woidacki, K.; Croy, B. A.; Zenclussen, A. C.

  Carbon Monoxide Promotes Proliferation of Uterine Natural Killer Cells and Remodeling of Spiral Arteries in Pregnant Hypertensive Heme Oxygenase-1 Mutant Mice

  Hypertension. 2014. 63 (3). pp. 580–588.

  DOI: 10.1161/HYPERTENSIONAHA.113.02403
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more publications

• Andere herausragende Auszeichnungen: New Investigator Award, American Society for Reproductive Immunology

  Zenclussen, Ana Claudia (Leipziger Forschungszentrum für Zivilisationserkrankungen (LIFE))

  awarded in 2002.
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• Andere Ehrungen: GEMI Grant

  Zenclussen, Ana Claudia (Leipziger Forschungszentrum für Zivilisationserkrankungen (LIFE))

  awarded in 2007 by Harvard/Karolinska.
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• Andere Stipendien/Forschungspreise: Rahel-Hirsch-Habilitationsstipendium

  Zenclussen, Ana Claudia (Leipziger Forschungszentrum für Zivilisationserkrankungen (LIFE))

  awarded in 2003.
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• Andere Stipendien/Forschungspreise: Alexander-von-Humboldt

  Zenclussen, Ana Claudia (Leipziger Forschungszentrum für Zivilisationserkrankungen (LIFE))

  awarded in 2001 by Alexander von Humboldt Stiftung.
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more awards