Markus Schwab
Molecular regulation of neural networks: from the nucleus to axon and synapse
Brain Dynamics Graduate School is happy to announce a new talk within our Seminar Series:
- PD Dr Markus Schwab
Paul Flechsig Institute of Neuropathology, University Hospital Leipzig
"Molecular regulation of neural networks: from the nucleus to axon and synapse"
07th June 2024, 12:00
Paul Flechsig Institute - Center of Neuropathology and Brain Research, Room 3093, Liebigstraße 19 (Haus C), 04103 Leipzig
Abstract:
The nervous system is an intricate network of neurons and glia cells. The goal of our research is to identify molecular mechanisms that regulate neuron-glia interactions and orchestrate the development and adult function of neural networks in the peripheral and central nervous system. Furthermore, we study pathological processes that compromise cellular communication and thereby promote the pathogenesis of neurological disorders.
We study these processes using genetically modified mice that permit spatially and temporally controlled genetic interventions. Our research is focused on two protein families, the neuronal basic helix-loop-helix transcription factors and neuronal growth factors, the neuregulins. These proteins are important regulators of axonal growth and myelination, and thus critically required for the formation of functional neural circuitry. In addition, these factors modulate synaptic functions and may contribute to learning and memory processes in the adult brain.